Protein Details: Potassium channel subfamily K member 4

Protein ID

ICDB_Pro_1592

Protein Name

Potassium channel subfamily K member 4

Gene Name

KCNK4; TRAAK

Organism

Homo sapiens (Human)

Length

393 amino acids

AlphaFoldDB

AF-Q9NYG8-F1-model_v4.pdb

Function

Voltage-insensitive potassium channel. Channel opening is triggered by mechanical forces that deform the membrane. Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening;with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).

Sequence

MRSTTLLALLALVLLYLVSGALVFRALEQPHEQQAQRELGEVREKFLRAHPCVSDQELGLLIKEVADALGGGADPETNSTSNSSHSAWDLGSAFFFSGTIITTIGYGNVALRTDAGRLFCIFYALVGIPLFGILLAGVGDRLGSSLRHGIGHIEAIFLKWHVPPELVRVLSAMLFLLIGCLLFVLTPTFVFCYMEDWSKLEAIYFVIVTLTTVGFGDYVAGADPRQDSPAYQPLVWFWILLGLAYFASVLTTIGNWLRVVSRRTRAEMGGLTAQAASWTGTVTARVTQRAGPAAPPPEKEQPLLPPPPCPAQPLGRPRSPSPPEKAQPPSPPTASALDYPSENLAFIDESSDTQSERGCPLPRAPRGRRRPNPPRKPVRPRGPGRPRDKGVPV

PDB Structures

3UM7 4I9W 4RUE 4RUF 4WFE 4WFF 4WFG 4WFH 7LJ4 7LJ5 7LJA 7LJB

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Facial Dysmorphism;Hypertrichosis;Epilepsy;Intellectual/Developmental Delay;And Gingival Overgrowth Syndrome and Gingival Overgrowth

Location

DOI ID

10.1016/s0169-328x(00)00183-2; 10.1016/s0014-5793(00)01388-0; 10.1016/s0169-328x(02)00157-2; 10.1038/nature04632; 10.1186/gb-2004-5-2-r8; 10.1016/j.ajhg.2018.09.001; 10.1126/science.1213808; 10.1073/pnas.1218950110; 10.1038/nature14013; 10.1016/j.neuron.2014.11.017

RefSeq

NP_001304019.1 [Q9NYG8-1]; NP_201567.1 [Q9NYG8-1]